Bernhard Fleckenstein Selected Research

Trans-Activators (Trans-Acting Factor)

12/2021	Characterizing the Interaction between the HTLV-1 Transactivator Tax-1 with Transcription Elongation Factor ELL2 and Its Impact on Viral Transactivation.
10/2020	A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells.
9/2014	The transcription elongation factor ELL2 is specifically upregulated in HTLV-1-infected T-cells and is dependent on the viral oncoprotein Tax.
9/2010	Elevated cyclic AMP levels in T lymphocytes transformed by human T-cell lymphotropic virus type 1.

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Bernhard Fleckenstein Research Topics

Disease

6	Neoplasms (Cancer) 01/2022 - 01/2008
5	Lymphoma (Lymphomas) 01/2018 - 05/2005
5	Infections 01/2018 - 08/2005
3	T-Cell Leukemia (Leukemia, T Cell) 01/2022 - 09/2014
3	Autoimmune Lymphoproliferative Syndrome 01/2018 - 12/2014
3	Carcinogenesis 06/2012 - 03/2006
2	Inflammation (Inflammations) 01/2021 - 03/2006
2	Brain Diseases (Brain Disorder) 01/2020 - 12/2016
2	Brain Neoplasms (Brain Tumor) 01/2020 - 12/2016
2	Viremia 01/2020 - 12/2016
2	Candidiasis (Moniliasis) 12/2018 - 09/2015
2	Reinfection 01/2018 - 01/2018
2	Lymphadenopathy 01/2018 - 09/2015
2	Job Syndrome (Hyper-IgE Syndrome) 09/2015 - 05/2014
2	Neoplasm Metastasis (Metastasis) 07/2014 - 03/2011
2	HIV Infections (HIV Infection) 01/2013 - 08/2005
2	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 03/2011 - 09/2010
1	Eosinophilia 01/2021
1	Glioblastoma (Glioblastoma Multiforme) 01/2020
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2020
1	Astrocytoma (Pilocytic Astrocytoma) 01/2020
1	Tuberculosis (Tuberculoses) 12/2018
1	Inborn Genetic Diseases (Disease, Hereditary) 12/2018
1	Otitis 01/2018
1	Hypergammaglobulinemia (Hyperimmunoglobulinemia) 01/2018
1	Lymphopenia (Lymphocytopenia) 01/2018
1	Anemia 01/2018
1	Disease Progression 12/2016
1	Glioma (Gliomas) 12/2016
1	Fanconi Anemia (Fanconi's Anemia) 10/2016
1	Atopic Dermatitis (Atopic Eczema) 09/2015
1	Virus Diseases (Viral Diseases) 09/2015
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 09/2015
1	Abscess 09/2015
1	Tyrosine Kinase 2 Deficiency 09/2015
1	Hepatomegaly 09/2015
1	Splenomegaly 09/2015
1	Cytopenia 09/2015
1	Focal Cortical Dysplasia 02/2015
1	Drug Resistant Epilepsy 02/2015
1	Eczema 05/2014
1	Mycoses (Diseases, Fungus) 05/2014
1	Acquired Immunodeficiency Syndrome (AIDS) 01/2010
1	Primary Effusion Lymphoma 01/2008

Drug/Important Bio-Agent (IBA)

8	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2005
6	Oncogene Proteins (Oncogene Protein)IBA 01/2022 - 05/2005
4	Trans-Activators (Trans-Acting Factor)IBA 12/2021 - 09/2010
3	Tumor Biomarkers (Tumor Markers)IBA 01/2022 - 03/2011
3	fascinIBA 01/2022 - 03/2011
3	Interleukin-12 (IL 12)IBA 12/2018 - 09/2015
3	Interleukin-23 (Interleukin 23)IBA 12/2018 - 09/2015
3	Immunoglobulin E (IgE)IBA 01/2018 - 05/2014
2	CytokinesIBA 01/2021 - 12/2018
2	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 01/2018 - 09/2015
2	Interleukin-10 (Interleukin 10)IBA 09/2015 - 09/2015
2	Fas Ligand Protein (Fas Ligand)IBA 09/2015 - 12/2014
2	Death Domain ReceptorsIBA 09/2015 - 12/2014
2	LigandsIBA 12/2014 - 06/2012
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 06/2012 - 05/2005
1	Interleukin-13IBA 01/2021
1	Interleukin-5 (Interleukin 5)IBA 01/2021
1	Antiviral Agents (Antivirals)IBA 01/2020
1	Immunoglobulins (Immunoglobulin)IBA 01/2018
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2018
1	Intravenous Immunoglobulins (IVIG)FDA Link 01/2018
1	2,6-dinitrotoluene (DNT)IBA 01/2018
1	Immunoglobulin G (IgG)IBA 12/2016
1	Dexamethasone (Maxidex)FDA LinkGeneric 12/2016
1	Interleukin-6 (Interleukin 6)IBA 09/2015
1	Mechanistic Target of Rapamycin Complex 1IBA 02/2015
1	TOR Serine-Threonine KinasesIBA 02/2015
1	Peptides (Polypeptides)IBA 01/2013
1	CD4 Antigens (CD4 Antigen)IBA 01/2013
1	AntibodiesIBA 06/2012
1	Biomarkers (Surrogate Marker)IBA 03/2011
1	viral interferon regulatory factorsIBA 01/2008
1	Transcription Factors (Transcription Factor)IBA 03/2006
1	Glycoproteins (Glycoprotein)IBA 08/2005
1	ChemokinesIBA 08/2005
1	AntigensIBA 08/2005

Therapy/Procedure

3	Therapeutics 01/2020 - 01/2010
2	Radiotherapy 01/2020 - 12/2016
1	Chemoradiotherapy 01/2020
1	Hematopoietic Stem Cell Transplantation 01/2018
1	Aftercare (After-Treatment) 12/2016